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Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium.
Herms A, Fernandez-Antoran D, Alcolea MP, Kalogeropoulou A, Banerjee U, Piedrafita G, Abby E, Valverde-Lopez JA, Ferreira IS, Caseda I, Bejar MT, Dentro SC, Vidal-Notari S, Ong SH, Colom B, Murai K, King C, Mahbubani K, Saeb-Parsy K, Lowe AR, Gerstung M, Jones PH. Herms A, et al. Nat Genet. 2024 Oct;56(10):2158-2173. doi: 10.1038/s41588-024-01875-8. Epub 2024 Sep 23. Nat Genet. 2024. PMID: 39313617 Free PMC article.
Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Herms A, Colom B, Piedrafita G, Kalogeropoulou A, Banerjee U, King C, Abby E, Murai K, Caseda I, Fernandez-Antoran D, Ong SH, Hall MWJ, Bryant C, Sood RK, Fowler JC, Pol A, Frezza C, Vanhaesebroeck B, Jones PH. Herms A, et al. Nat Genet. 2024 Oct;56(10):2144-2157. doi: 10.1038/s41588-024-01891-8. Epub 2024 Aug 21. Nat Genet. 2024. PMID: 39169259 Free PMC article.