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Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution.
Elsner F, Hoffmann M, Fahrioglu-Yamaci R, Czyz Z, Feliciello G, Mederer T, Polzer B, Treitschke S, Rümmele P, Weber F, Wiesinger H, Robold T, Sziklavari Z, Sienel W, Hofmann HS, Klein CA. Elsner F, et al. J Pathol. 2022 Nov;258(3):250-263. doi: 10.1002/path.5996. Epub 2022 Sep 23. J Pathol. 2022. PMID: 36148685
Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Werner-Klein M, Scheitler S, Hoffmann M, Hodak I, Dietz K, Lehnert P, Naimer V, Polzer B, Treitschke S, Werno C, Markiewicz A, Weidele K, Czyz Z, Hohenleutner U, Hafner C, Haferkamp S, Berneburg M, Rümmele P, Ulmer A, Klein CA. Werner-Klein M, et al. Nat Commun. 2018 Feb 9;9(1):595. doi: 10.1038/s41467-017-02674-y. Nat Commun. 2018. PMID: 29426936 Free PMC article.