3R01 NS027699-25S1/NS/NINDS NIH HHS/United States[Grants and Funding] - Search Results

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A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.

Lasagna-Reeves CA, Rousseaux MW, Guerrero-Muñoz MJ, Park J, Jafar-Nejad P, Richman R, Lu N, Sengupta U, Litvinchuk A, Orr HT, Kayed R, Zoghbi HY. Lasagna-Reeves CA, et al. Elife. 2015 May 19;4:e07558. doi: 10.7554/eLife.07558. Elife. 2015. PMID: 25988806 Free PMC article.

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes.

Lasagna-Reeves CA, Rousseaux MW, Guerrero-Munoz MJ, Vilanova-Velez L, Park J, See L, Jafar-Nejad P, Richman R, Orr HT, Kayed R, Zoghbi HY. Lasagna-Reeves CA, et al. Elife. 2015 Dec 17;4:e10891. doi: 10.7554/eLife.10891. Elife. 2015. PMID: 26673892 Free PMC article.

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