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A localizing nanocarrier formulation enables multi-target immune responses to multivalent replicating RNA with limited systemic inflammation.
Kimura T, Leal JM, Simpson A, Warner NL, Berube BJ, Archer JF, Park S, Kurtz R, Hinkley T, Nicholes K, Sharma S, Duthie MS, Berglund P, Reed SG, Khandhar AP, Erasmus JH. Kimura T, et al. Mol Ther. 2023 Aug 2;31(8):2360-2375. doi: 10.1016/j.ymthe.2023.06.017. Epub 2023 Jul 3. Mol Ther. 2023. PMID: 37403357 Free PMC article.
An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates.
Erasmus JH, Khandhar AP, O'Connor MA, Walls AC, Hemann EA, Murapa P, Archer J, Leventhal S, Fuller JT, Lewis TB, Draves KE, Randall S, Guerriero KA, Duthie MS, Carter D, Reed SG, Hawman DW, Feldmann H, Gale M Jr, Veesler D, Berglund P, Fuller DH. Erasmus JH, et al. Sci Transl Med. 2020 Aug 5;12(555):eabc9396. doi: 10.1126/scitranslmed.abc9396. Epub 2020 Jul 20. Sci Transl Med. 2020. PMID: 32690628 Free PMC article.