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Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression.
Xiong Y, Qiu F, Piao W, Song C, Wahl LM, Medvedev AE. Xiong Y, et al. J Biol Chem. 2011 Mar 11;286(10):7905-7916. doi: 10.1074/jbc.M110.182873. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220427 Free PMC article.
TLR4/MyD88/PI3K interactions regulate TLR4 signaling.
Laird MH, Rhee SH, Perkins DJ, Medvedev AE, Piao W, Fenton MJ, Vogel SN. Laird MH, et al. J Leukoc Biol. 2009 Jun;85(6):966-77. doi: 10.1189/jlb.1208763. Epub 2009 Mar 16. J Leukoc Biol. 2009. PMID: 19289601 Free PMC article.