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The CALR mutations enhance the expression of the immunosuppressive proteins GARP and LAP on peripheral blood lymphocytes through increased binding of activated platelets.
Br J Haematol. 2024 Oct;205(4):1417-1429. doi: 10.1111/bjh.19711. Epub 2024 Aug 20.
Br J Haematol. 2024.
PMID: 39161981
Platelets in myeloproliferative neoplasms have a distinct transcript signature in the presence of marrow fibrosis.
Guo BB, Linden MD, Fuller KA, Phillips M, Mirzai B, Wilson L, Chuah H, Liang J, Howman R, Grove CS, Malherbe JA, Leahy MF, Allcock RJ, Erber WN.
Guo BB, et al.
Br J Haematol. 2020 Jan;188(2):272-282. doi: 10.1111/bjh.16152. Epub 2019 Aug 19.
Br J Haematol. 2020.
PMID: 31426129
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