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Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression.
Stepanova V, Jayaraman PS, Zaitsev SV, Lebedeva T, Bdeir K, Kershaw R, Holman KR, Parfyonova YV, Semina EV, Beloglazova IB, Tkachuk VA, Cines DB. Stepanova V, et al. J Biol Chem. 2016 Jul 15;291(29):15029-45. doi: 10.1074/jbc.M115.678490. Epub 2016 May 4. J Biol Chem. 2016. PMID: 27151212 Free PMC article.
Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.
Makarova AM, Lebedeva TV, Nassar T, Higazi AA, Xue J, Carinato ME, Bdeir K, Cines DB, Stepanova V. Makarova AM, et al. J Biol Chem. 2011 Jul 1;286(26):23044-53. doi: 10.1074/jbc.M110.210195. Epub 2011 May 3. J Biol Chem. 2011. PMID: 21540184 Free PMC article.
Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.
Kapustin A, Stepanova V, Aniol N, Cines DB, Poliakov A, Yarovoi S, Lebedeva T, Wait R, Ryzhakov G, Parfyonova Y, Gursky Y, Yanagisawa H, Minashkin M, Beabealashvilli R, Vorotnikov A, Bobik A, Tkachuk V. Kapustin A, et al. Biochem J. 2012 Apr 15;443(2):491-503. doi: 10.1042/BJ20110348. Biochem J. 2012. PMID: 22280367 Free PMC article.