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Year Number of Results
1823 1
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1930 1
1943 1
1944 3
1945 166
1946 356
1947 510
1948 675
1949 847
1950 1399
1951 1439
1952 1465
1953 1350
1954 1248
1955 1327
1956 1316
1957 1326
1958 1227
1959 677
1960 318
1961 299
1962 291
1963 772
1964 1289
1965 1277
1966 1121
1967 1216
1968 1317
1969 1303
1970 1303
1971 1320
1972 1250
1973 1076
1974 1057
1975 1078
1976 1098
1977 1150
1978 1179
1979 1202
1980 1140
1981 1150
1982 1242
1983 1254
1984 1326
1985 1339
1986 1395
1987 1343
1988 1395
1989 1410
1990 1406
1991 1261
1992 1235
1993 1213
1994 1189
1995 1139
1996 1173
1997 1201
1998 1169
1999 1201
2000 1222
2001 1289
2002 1304
2003 1400
2004 1493
2005 1631
2006 1904
2007 1876
2008 1917
2009 1897
2010 2163
2011 2392
2012 2432
2013 2851
2014 3955
2015 5105
2016 6617
2017 8051
2018 10129
2019 11719
2020 13067
2021 14524
2022 14789
2023 13822
2024 14088
2025 309

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189,011 results

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Page 1
CRISPR-Cas for genome editing: Classification, mechanism, designing and applications.
Bhatia S, Pooja, Yadav SK. Bhatia S, et al. Int J Biol Macromol. 2023 May 31;238:124054. doi: 10.1016/j.ijbiomac.2023.124054. Epub 2023 Mar 17. Int J Biol Macromol. 2023. PMID: 36933595 Review.
Clustered regularly interspersed short pallindromic repeats (CRISPR) and CRISPR associated proteins (Cas) system (CRISPR-Cas) came into light as prokaryotic defence mechanism for adaptive immune response. ...The locus containing spacers interspersed repeats is furth …
Clustered regularly interspersed short pallindromic repeats (CRISPR) and CRISPR associated proteins (Cas) system (CRISPR-Cas) …
CRISPR-Cas bioinformatics.
Alkhnbashi OS, Meier T, Mitrofanov A, Backofen R, Voß B. Alkhnbashi OS, et al. Methods. 2020 Feb 1;172:3-11. doi: 10.1016/j.ymeth.2019.07.013. Epub 2019 Jul 19. Methods. 2020. PMID: 31326596 Review.
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) are essential genetic elements in many archaeal and bacterial genomes, playing a key role in a prokaryote adaptive immune system against invasive foreign elements. In rec …
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) are essential genetic elements …
A Review on the Mechanism and Applications of CRISPR/Cas9/Cas12/Cas13/Cas14 Proteins Utilized for Genome Engineering.
Hillary VE, Ceasar SA. Hillary VE, et al. Mol Biotechnol. 2023 Mar;65(3):311-325. doi: 10.1007/s12033-022-00567-0. Epub 2022 Sep 27. Mol Biotechnol. 2023. PMID: 36163606 Free PMC article. Review.
Cas variants stimulated genetic research and propelled the CRISPR/Cas tool for manipulating and editing nucleic acid sequences of living cells of diverse organisms. This review aims to provide detail on two classes (class 1 and 2) of the CRISPR/Cas system, an …
Cas variants stimulated genetic research and propelled the CRISPR/Cas tool for manipulating and editing nucleic acid sequences …
Design and analysis of CRISPR-Cas experiments.
Hanna RE, Doench JG. Hanna RE, et al. Nat Biotechnol. 2020 Jul;38(7):813-823. doi: 10.1038/s41587-020-0490-7. Epub 2020 Apr 13. Nat Biotechnol. 2020. PMID: 32284587 Review.
A large and ever-expanding set of CRISPR-Cas systems now enables the rapid and flexible manipulation of genomes in both targeted and large-scale experiments. Numerous software tools and analytical methods have been developed for the design and analysis of CRISPR-Cas …
A large and ever-expanding set of CRISPR-Cas systems now enables the rapid and flexible manipulation of genomes in both targeted and …
Annotation and Classification of CRISPR-Cas Systems.
Makarova KS, Koonin EV. Makarova KS, et al. Methods Mol Biol. 2015;1311:47-75. doi: 10.1007/978-1-4939-2687-9_4. Methods Mol Biol. 2015. PMID: 25981466 Free PMC article. Review.
To this end, a multipronged approach has been developed that combines phylogenetic analysis of the conserved Cas proteins with comparison of gene repertoires and arrangements in CRISPR-Cas loci. ...Moreover, most of the cas genes evolve rapidly, complicating …
To this end, a multipronged approach has been developed that combines phylogenetic analysis of the conserved Cas proteins with compar …
CRISPR-Cas System: The Current and Emerging Translational Landscape.
Bhokisham N, Laudermilch E, Traeger LL, Bonilla TD, Ruiz-Estevez M, Becker JR. Bhokisham N, et al. Cells. 2023 Apr 7;12(8):1103. doi: 10.3390/cells12081103. Cells. 2023. PMID: 37190012 Free PMC article. Review.
CRISPR-Cas technology has rapidly changed life science research and human medicine. The ability to add, remove, or edit human DNA sequences has transformative potential for treating congenital and acquired human diseases. ...Here, we review the current landscape of clinica …
CRISPR-Cas technology has rapidly changed life science research and human medicine. The ability to add, remove, or edit human DNA seq …
CRISPR/Cas-based nucleic acid detection strategies: Trends and challenges.
Zhou J, Li Z, Seun Olajide J, Wang G. Zhou J, et al. Heliyon. 2024 Feb 14;10(4):e26179. doi: 10.1016/j.heliyon.2024.e26179. eCollection 2024 Feb 29. Heliyon. 2024. PMID: 38390187 Free PMC article. Review.
CRISPR/Cas systems have become integral parts of nucleic acid detection apparatus and biosensors. ...Finally, important considerations are offered for the improvement of CRISPR/Cas-based nucleic acid testing....
CRISPR/Cas systems have become integral parts of nucleic acid detection apparatus and biosensors. ...Finally, important consideration …
Phage-Encoded Anti-CRISPR Defenses.
Stanley SY, Maxwell KL. Stanley SY, et al. Annu Rev Genet. 2018 Nov 23;52:445-464. doi: 10.1146/annurev-genet-120417-031321. Epub 2018 Sep 12. Annu Rev Genet. 2018. PMID: 30208287 Review.
In response to CRISPR-Cas, phages have evolved protein inhibitors known as anti-CRISPRs. Here, we describe the discovery and mechanisms of action of anti-CRISPR proteins. We discuss the potential impact of anti-CRISPRs on bacterial evolution, speculate on their evolutionar …
In response to CRISPR-Cas, phages have evolved protein inhibitors known as anti-CRISPRs. Here, we describe the discovery and mechanis …
Functional Genomics via CRISPR-Cas.
Ford K, McDonald D, Mali P. Ford K, et al. J Mol Biol. 2019 Jan 4;431(1):48-65. doi: 10.1016/j.jmb.2018.06.034. Epub 2018 Jun 28. J Mol Biol. 2019. PMID: 29959923 Free PMC article. Review.
The programmability of CRISPR-Cas has proven especially useful for probing genomic function in high-throughput. Facile single-guide RNA library synthesis allows CRISPR-Cas screening to rapidly investigate the functional consequences of genomic, transcriptomic, and e …
The programmability of CRISPR-Cas has proven especially useful for probing genomic function in high-throughput. Facile single-guide R …
189,011 results
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