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Spatial and Temporal Visualization of Polymorphic Transformations in Pharmaceutical Tablets.

Gasol-Cardona J, Ward MR, Gutowski O, Drnec J, Jandl C, Stam D, Maloney AGP, Markl D, Price SWT, Oswald IDH. Gasol-Cardona J, et al. Angew Chem Int Ed Engl. 2024 Nov 15:e202412976. doi: 10.1002/anie.202412976. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 39545584

Crystal size, shape, and conformational changes drive both the disappearance and reappearance of ritonavir polymorphs in the mill.

Sacchi P, Wright SE, Neoptolemou P, Lampronti GI, Rajagopalan AK, Kras W, Evans CL, Hodgkinson P, Cruz-Cabeza AJ. Sacchi P, et al. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2319127121. doi: 10.1073/pnas.2319127121. Epub 2024 Apr 1. Proc Natl Acad Sci U S A. 2024. PMID: 38557191 Free PMC article.

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