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Chromatin and beyond: the multitasking roles for SIRT6.
Kugel S, Mostoslavsky R. Kugel S, et al. Trends Biochem Sci. 2014 Feb;39(2):72-81. doi: 10.1016/j.tibs.2013.12.002. Epub 2014 Jan 14. Trends Biochem Sci. 2014. PMID: 24438746 Free PMC article. Review.
Assaying chromatin sirtuins.
Zhong L, Martinez-Pastor B, Silberman DM, Sebastian C, Mostoslavsky R. Zhong L, et al. Methods Mol Biol. 2013;1077:149-163. doi: 10.1007/978-1-62703-637-5_10. Methods Mol Biol. 2013. PMID: 24014405 Free PMC article.
Sirtuins, metabolism, and DNA repair.
Choi JE, Mostoslavsky R. Choi JE, et al. Curr Opin Genet Dev. 2014 Jun;26:24-32. doi: 10.1016/j.gde.2014.05.005. Epub 2014 Jul 5. Curr Opin Genet Dev. 2014. PMID: 25005742 Free PMC article. Review.
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. Sebastián C, et al. Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047. Cell. 2012. PMID: 23217706 Free PMC article.
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.
Etchegaray JP, Chavez L, Huang Y, Ross KN, Choi J, Martinez-Pastor B, Walsh RM, Sommer CA, Lienhard M, Gladden A, Kugel S, Silberman DM, Ramaswamy S, Mostoslavsky G, Hochedlinger K, Goren A, Rao A, Mostoslavsky R. Etchegaray JP, et al. Nat Cell Biol. 2015 May;17(5):545-57. doi: 10.1038/ncb3147. Epub 2015 Apr 27. Nat Cell Biol. 2015. PMID: 25915124 Free PMC article.