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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. McQuade A, et al. Nat Commun. 2020 Oct 23;11(1):5370. doi: 10.1038/s41467-020-19227-5. Nat Commun. 2020. PMID: 33097708 Free PMC article.
Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins.
Fote GM, Eapen VV, Lim RG, Yu C, Salazar L, McClure NR, McKnight J, Nguyen TB, Heath MC, Lau AL, Villamil MA, Miramontes R, Kratter IH, Finkbeiner S, Reidling JC, Paulo JA, Kaiser P, Huang L, Housman DE, Thompson LM, Steffan JS. Fote GM, et al. Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2319091121. doi: 10.1073/pnas.2319091121. Epub 2024 Jul 29. Proc Natl Acad Sci U S A. 2024. PMID: 39074279 Free PMC article.
Plasma Sphingomyelins in Late-Onset Alzheimer's Disease.
Fote G, Wu J, Mapstone M, Macciardi F, Fiandaca MS, Federoff HJ. Fote G, et al. J Alzheimers Dis. 2021;83(3):1161-1171. doi: 10.3233/JAD-200871. J Alzheimers Dis. 2021. PMID: 34397408 Free PMC article.
APOE4 dysregulates autophagy in cultured cells.
Fote GM, Steffan JS. Fote GM, et al. Autophagy Rep. 2022;1(1):29-33. doi: 10.1080/27694127.2022.2040767. Epub 2022 Mar 22. Autophagy Rep. 2022. PMID: 38912292 Free PMC article.