F31 GM111049/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

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Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.

Reynoso E, Liu H, Li L, Yuan AL, Chen S, Wang Z. Reynoso E, et al. J Biol Chem. 2017 Oct 20;292(42):17514-17524. doi: 10.1074/jbc.M117.799353. Epub 2017 Sep 6. J Biol Chem. 2017. PMID: 28878015 Free PMC article.

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis.

Liu S, Liu H, Johnston A, Hanna-Addams S, Reynoso E, Xiang Y, Wang Z. Liu S, et al. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7450-E7459. doi: 10.1073/pnas.1707531114. Epub 2017 Aug 21. Proc Natl Acad Sci U S A. 2017. PMID: 28827318 Free PMC article.

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