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Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis.
Winnick JJ, Kraft G, Gregory JM, Edgerton DS, Williams P, Hajizadeh IA, Kamal MZ, Smith M, Farmer B, Scott M, Neal D, Donahue EP, Allen E, Cherrington AD. Winnick JJ, et al. J Clin Invest. 2016 Jun 1;126(6):2236-48. doi: 10.1172/JCI79895. Epub 2016 May 3. J Clin Invest. 2016. PMID: 27140398 Free PMC article.
Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs.
Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Madsen P, Kjeldsen TB, Hostrup S, Brand CL, Fledelius C, Nishimura E, Cherrington AD. Gregory JM, et al. Diabetes Obes Metab. 2019 Oct;21(10):2294-2304. doi: 10.1111/dom.13808. Epub 2019 Jul 8. Diabetes Obes Metab. 2019. PMID: 31183936 Free PMC article.