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A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.
Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS. Lee E, et al. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2308941120. doi: 10.1073/pnas.2308941120. Epub 2023 Oct 2. Proc Natl Acad Sci U S A. 2023. PMID: 37782785 Free PMC article.
A Bile Duct-on-a-Chip With Organ-Level Functions.
Du Y, Khandekar G, Llewellyn J, Polacheck W, Chen CS, Wells RG. Du Y, et al. Hepatology. 2020 Apr;71(4):1350-1363. doi: 10.1002/hep.30918. Epub 2019 Oct 28. Hepatology. 2020. PMID: 31465556 Free PMC article.
Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury.
McCurley A, Alimperti S, Campos-Bilderback SB, Sandoval RM, Calvino JE, Reynolds TL, Quigley C, Mugford JW, Polacheck WJ, Gomez IG, Dovey J, Marsh G, Huang A, Qian F, Weinreb PH, Dolinski BM, Moore S, Duffield JS, Chen CS, Molitoris BA, Violette SM, Crackower MA. McCurley A, et al. J Am Soc Nephrol. 2017 Jun;28(6):1741-1752. doi: 10.1681/ASN.2016020200. Epub 2017 Jan 6. J Am Soc Nephrol. 2017. PMID: 28062569 Free PMC article.