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Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses.
Schnepf D, Crotta S, Thamamongood T, Stanifer M, Polcik L, Ohnemus A, Vier J, Jakob C, Llorian M, Gad HH, Hartmann R, Strobl B, Kirschnek S, Boulant S, Schwemmle M, Wack A, Staeheli P. Schnepf D, et al. Sci Immunol. 2021 May 14;6(59):eabd5318. doi: 10.1126/sciimmunol.abd5318. Sci Immunol. 2021. PMID: 33990378 Free PMC article.
Impaired immune response drives age-dependent severity of COVID-19.
Beer J, Crotta S, Breithaupt A, Ohnemus A, Becker J, Sachs B, Kern L, Llorian M, Ebert N, Labroussaa F, Nhu Thao TT, Trueeb BS, Jores J, Thiel V, Beer M, Fuchs J, Kochs G, Wack A, Schwemmle M, Schnepf D. Beer J, et al. J Exp Med. 2022 Dec 5;219(12):e20220621. doi: 10.1084/jem.20220621. Epub 2022 Sep 21. J Exp Med. 2022. PMID: 36129445 Free PMC article.
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity.
Cabeza-Cabrerizo M, Minutti CM, da Costa MP, Cardoso A, Jenkins RP, Kulikauskaite J, Buck MD, Piot C, Rogers N, Crotta S, Whittaker L, Encabo HH, McCauley JW, Allen JE, Pasparakis M, Wack A, Sahai E, Reis e Sousa C. Cabeza-Cabrerizo M, et al. Sci Immunol. 2021 Nov 5;6(65):eabi9331. doi: 10.1126/sciimmunol.abi9331. Epub 2021 Nov 5. Sci Immunol. 2021. PMID: 34739343 Free PMC article.
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.
Wing PAC, Prange-Barczynska M, Cross A, Crotta S, Orbegozo Rubio C, Cheng X, Harris JM, Zhuang X, Johnson RL, Ryan KA, Hall Y, Carroll MW, Issa F, Balfe P, Wack A, Bishop T, Salguero FJ, McKeating JA. Wing PAC, et al. PLoS Pathog. 2022 Sep 6;18(9):e1010807. doi: 10.1371/journal.ppat.1010807. eCollection 2022 Sep. PLoS Pathog. 2022. PMID: 36067210 Free PMC article.
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