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Progress on the development of Class A GPCR-biased ligands.
Morales P, Scharf MM, Bermudez M, Egyed A, Franco R, Hansen OK, Jagerovic N, Jakubík J, Keserű GM, Kiss DJ, Kozielewicz P, Larsen O, Majellaro M, Mallo-Abreu A, Navarro G, Prieto-Díaz R, Rosenkilde MM, Sotelo E, Stark H, Werner T, Wingler LM. Morales P, et al. Br J Pharmacol. 2024 Sep 11. doi: 10.1111/bph.17301. Online ahead of print. Br J Pharmacol. 2024. PMID: 39261899 Review.
YAT2150 is irresistible in Plasmodium falciparum and active against Plasmodium vivax and Leishmania clinical isolates.
Bouzón-Arnáiz I, Rawat M, Coyle R, Feufack-Donfack LB, Ea M, Orban A, Popovici J, Román-Álamo L, Fallica AN, Domínguez-Asenjo B, Moreno J, Arce EM, Mallo-Abreu A, Muñoz-Torrero D, Lee MCS, Fernàndez-Busquets X. Bouzón-Arnáiz I, et al. Sci Rep. 2025 Jan 23;15(1):2941. doi: 10.1038/s41598-025-85346-y. Sci Rep. 2025. PMID: 39848983 Free article.