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Latent cytokines for targeted therapy of inflammatory disorders.
Mullen L, Adams G, Layward L, Vessillier S, Annenkov A, Mittal G, Rigby A, Sclanders M, Baker D, Gould D, Chernajovsky Y. Mullen L, et al. Expert Opin Drug Deliv. 2014 Jan;11(1):101-10. doi: 10.1517/17425247.2014.863872. Epub 2013 Dec 3. Expert Opin Drug Deliv. 2014. PMID: 24294995 Review.
Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β.
Mullen L, Rigby A, Sclanders M, Adams G, Mittal G, Colston J, Fatah R, Subang C, Foster J, Francis-West P, Köster M, Hauser H, Layward L, Vessillier S, Annenkov A, Al-Izki S, Pryce G, Bolton C, Baker D, Gould DJ, Chernajovsky Y. Mullen L, et al. Expert Opin Drug Deliv. 2014 Jan;11(1):5-16. doi: 10.1517/17425247.2013.839655. Epub 2013 Sep 27. Expert Opin Drug Deliv. 2014. PMID: 24073618