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Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages.

Jubrail J, Morris P, Bewley MA, Stoneham S, Johnston SA, Foster SJ, Peden AA, Read RC, Marriott HM, Dockrell DH. Jubrail J, et al. Cell Microbiol. 2016 Jan;18(1):80-96. doi: 10.1111/cmi.12485. Epub 2015 Sep 2. Cell Microbiol. 2016. PMID: 26248337 Free PMC article.

A mathematical model shows macrophages delay Staphylococcus aureus replication, but limitations in microbicidal capacity restrict bacterial clearance.

Best A, Jubrail J, Boots M, Dockrell D, Marriott H. Best A, et al. J Theor Biol. 2020 Jul 21;497:110256. doi: 10.1016/j.jtbi.2020.110256. Epub 2020 Apr 15. J Theor Biol. 2020. PMID: 32304686 Free PMC article.

Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

Daigneault M, De Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MK, Dockrell DH. Daigneault M, et al. PLoS Pathog. 2012;8(7):e1002814. doi: 10.1371/journal.ppat.1002814. Epub 2012 Jul 19. PLoS Pathog. 2012. PMID: 22829769 Free PMC article.

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