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Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression.
Wortzel I, Seo Y, Akano I, Shaashua L, Tobias GC, Hebert J, Kim KA, Kim D, Dror S, Liu Y, Azrak GC, Cioffi M, Johnson KE, Hennika T, Twerski MZ, Kushner A, Math R, Han YD, Han DH, Jung M, Park J, Paik S, Shin JS, Lee MG, Russo MV, Zakheim D, Barnes J, Mehta S, Manova K, Schwartz RE, Thakur BK, Boudreau N, Matei I, Zhang H, Sidoli S, Bromberg J, David Y, Kim HS, Lyden D. Wortzel I, et al. Nat Cancer. 2024 Dec;5(12):1815-1833. doi: 10.1038/s43018-024-00862-6. Epub 2024 Dec 3. Nat Cancer. 2024. PMID: 39627554