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Metoprolol and coronary artery bypass grafting surgery: does intraoperative metoprolol attenuate acute beta-adrenergic receptor desensitization during cardiac surgery?
Booth JV, Ward EE, Colgan KC, Funk BL, El-Moalem H, Smith MP, Milano C, Smith PK, Newman MF, Schwinn DA; Duke Heart Center Perioperative Desensitization Group. Booth JV, et al. Anesth Analg. 2004 May;98(5):1224-31, table of contents. doi: 10.1213/01.ane.0000112325.66981.03. Anesth Analg. 2004. PMID: 15105192 Clinical Trial.
Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group.
Booth JV, Landolfo KP, Chesnut LC, Bennett-Guerrero E, Gerhardt MA, Atwell DM, El-Moalem HE, Smith MS, Funk BL, Kuhn CM, Kwatra MM, Schwinn DA. Booth JV, et al. Anesthesiology. 1998 Sep;89(3):602-11. doi: 10.1097/00000542-199809000-00008. Anesthesiology. 1998. PMID: 9743395