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Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting.
Jeger-Madiot R, Planas D, Staropoli I, Debarnot H, Kervevan J, Mary H, Collina C, Fonseca BF, Robinot R, Gellenoncourt S, Schwartz O, Ewart L, Bscheider M, Gobaa S, Chakrabarti LA. Jeger-Madiot R, et al. J Exp Med. 2024 Oct 7;221(10):e20240289. doi: 10.1084/jem.20240289. Epub 2024 Sep 6. J Exp Med. 2024. PMID: 39240335 Free article.
Irreversible inhibitors of the proline racemase unveil innovative mechanism of action as antibacterial agents against Clostridioides difficile.
Gateau C, Melo GD, Uriac P, Tasseau O, Renault J, Blondel A, Gouault N, Barbut F, Minoprio P. Gateau C, et al. Chem Biol Drug Des. 2022 Apr;99(4):513-526. doi: 10.1111/cbdd.14005. Epub 2022 Jan 5. Chem Biol Drug Des. 2022. PMID: 34918458 Free article.
However, C. difficile, due to an increased incidence in recent years, is considered as a major cause of health threat. In this work, we have taken into account the similarity between TcPRAC and CdPRAC enzymes to design new inhibitors of CdPRAC. ...
However, C. difficile, due to an increased incidence in recent years, is considered as a major cause of health threat. In this work, …