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Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.
Kavousi M, Bos MM, Barnes HJ, Lino Cardenas CL, Wong D, Lu H, Hodonsky CJ, Landsmeer LPL, Turner AW, Kho M, Hasbani NR, de Vries PS, Bowden DW, Chopade S, Deelen J, Benavente ED, Guo X, Hofer E, Hwang SJ, Lutz SM, Lyytikäinen LP, Slenders L, Smith AV, Stanislawski MA, van Setten J, Wong Q, Yanek LR, Becker DM, Beekman M, Budoff MJ, Feitosa MF, Finan C, Hilliard AT, Kardia SLR, Kovacic JC, Kral BG, Langefeld CD, Launer LJ, Malik S, Hoesein FAAM, Mokry M, Schmidt R, Smith JA, Taylor KD, Terry JG, van der Grond J, van Meurs J, Vliegenthart R, Xu J, Young KA, Zilhão NR, Zweiker R, Assimes TL, Becker LC, Bos D, Carr JJ, Cupples LA, de Kleijn DPV, de Winther M, den Ruijter HM, Fornage M, Freedman BI, Gudnason V, Hingorani AD, Hokanson JE, Ikram MA, Išgum I, Jacobs DR Jr, Kähönen M, Lange LA, Lehtimäki T, Pasterkamp G, Raitakari OT, Schmidt H, Slagboom PE, Uitterlinden AG, Vernooij MW, Bis JC, Franceschini N, Psaty BM, Post WS, Rotter JI, Björkegren JLM, O'Donnell CJ, Bielak LF, Peyser PA, Malhotra R, van der Laan SW, Miller CL. Kavousi M, et al. Nat Genet. 2023 Oct;55(10):1651-1664. doi: 10.1038/s41588-023-01518-4. Epub 2023 Sep 28. Nat Genet. 2023. PMID: 37770635 Free PMC article.
Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta.
Chou EL, Chaffin M, Simonson B, Pirruccello JP, Akkad AD, Nekoui M, Lino Cardenas CL, Bedi KC Jr, Nash C, Juric D, Stone JR, Isselbacher EM, Margulies KB, Klattenhoff C, Ellinor PT, Lindsay ME. Chou EL, et al. Arterioscler Thromb Vasc Biol. 2022 Nov;42(11):1355-1374. doi: 10.1161/ATVBAHA.122.317953. Epub 2022 Sep 29. Arterioscler Thromb Vasc Biol. 2022. PMID: 36172868 Free PMC article.
Treatment of calcific arterial disease via enhancement of autophagy using GSK343.
Lino Cardenas CL, Jiang W, Kajuluri LP, Singh K, Ostrom K, Li R, Cherbonneau F, Boerboom S, Birchenough C, Roh K, Chou EL, Shahrooz Z, Nicholson C, Johnson AL, Lee S, Ichinose F, Bloch DB, Nigwekar S, Ellinor PT, Musolino P, Lindsay ME, Dou Z, Miller CL, Malhotra R. Lino Cardenas CL, et al. iScience. 2023 Oct 29;26(11):108360. doi: 10.1016/j.isci.2023.108360. eCollection 2023 Nov 17. iScience. 2023. PMID: 38033629 Free PMC article.
FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells.
Wong D, Auguste G, Lino Cardenas CL, Turner AW, Chen Y, Song Y, Ma L, Perry RN, Aherrahrou R, Kuppusamy M, Yang C, Mosquera JV, Dube CJ, Khan MD, Palmore M, Kalra J, Kavousi M, Peyser PA, Matic L, Hedin U, Manichaikul A, Sonkusare SK, Civelek M, Kovacic JC, Björkegren JLM, Malhotra R, Miller CL. Wong D, et al. Circ Res. 2023 Apr 28;132(9):1144-1161. doi: 10.1161/CIRCRESAHA.122.321692. Epub 2023 Apr 5. Circ Res. 2023. PMID: 37017084 Free PMC article.
Co-occurring pathogenic variants in 6q27 associated with dementia spectrum disorders in a Peruvian family.
Alvarez KLF, Aguilar-Pineda JA, Ortiz-Manrique MM, Paredes-Calderon MF, Cardenas-Quispe BC, Vera-Lopez KJ, Goyzueta-Mamani LD, Chavez-Fumagalli MA, Davila-Del-Carpio G, Peralta-Mestas A, Musolino PL, Lino Cardenas CL. Alvarez KLF, et al. Front Mol Neurosci. 2023 Feb 16;16:1104585. doi: 10.3389/fnmol.2023.1104585. eCollection 2023. Front Mol Neurosci. 2023. PMID: 36873109 Free PMC article.