K08 DK088872/DK/NIDDK NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2011	1
2012	2
2013	7
2014	2
2015	1
2017	4
2023	1
2025	0

1

Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance.

Douglass JD, Ness KM, Valdearcos M, Wyse-Jackson A, Dorfman MD, Frey JM, Fasnacht RD, Santiago OD, Niraula A, Banerjee J, Robblee M, Koliwad SK, Thaler JP. Douglass JD, et al. Cell Metab. 2023 Sep 5;35(9):1613-1629.e8. doi: 10.1016/j.cmet.2023.07.008. Epub 2023 Aug 11. Cell Metab. 2023. PMID: 37572666 Free PMC article.

2

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW. Thaler JP, et al. J Clin Invest. 2012 Jan;122(1):153-62. doi: 10.1172/JCI59660. Epub 2011 Dec 27. J Clin Invest. 2012. PMID: 22201683 Free PMC article.

3

Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.

Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK. Valdearcos M, et al. Cell Metab. 2017 Jul 5;26(1):185-197.e3. doi: 10.1016/j.cmet.2017.05.015. Cell Metab. 2017. PMID: 28683286 Free PMC article.

4

Hypothalamic inflammation and gliosis in obesity.

Dorfman MD, Thaler JP. Dorfman MD, et al. Curr Opin Endocrinol Diabetes Obes. 2015 Oct;22(5):325-30. doi: 10.1097/MED.0000000000000182. Curr Opin Endocrinol Diabetes Obes. 2015. PMID: 26192704 Free PMC article. Review.

5

Food for thought: hormonal, experiential, and neural influences on feeding and obesity.

Karatsoreos IN, Thaler JP, Borgland SL, Champagne FA, Hurd YL, Hill MN. Karatsoreos IN, et al. J Neurosci. 2013 Nov 6;33(45):17610-6. doi: 10.1523/JNEUROSCI.3452-13.2013. J Neurosci. 2013. PMID: 24198352 Free PMC article. Review.

6

Hypothalamic inflammation: marker or mechanism of obesity pathogenesis?

Thaler JP, Guyenet SJ, Dorfman MD, Wisse BE, Schwartz MW. Thaler JP, et al. Diabetes. 2013 Aug;62(8):2629-34. doi: 10.2337/db12-1605. Diabetes. 2013. PMID: 23881189 Free PMC article. Review. No abstract available.

7

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation.

Douglass JD, Dorfman MD, Fasnacht R, Shaffer LD, Thaler JP. Douglass JD, et al. Mol Metab. 2017 Jan 28;6(4):366-373. doi: 10.1016/j.molmet.2017.01.010. eCollection 2017 Apr. Mol Metab. 2017. PMID: 28377875 Free PMC article.

8

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.

Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. Dorfman MD, et al. Diabetes. 2017 Apr;66(4):920-934. doi: 10.2337/db16-0482. Epub 2017 Jan 10. Diabetes. 2017. PMID: 28073831 Free PMC article.

9

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice.

Dorfman MD, Krull JE, Douglass JD, Fasnacht R, Lara-Lince F, Meek TH, Shi X, Damian V, Nguyen HT, Matsen ME, Morton GJ, Thaler JP. Dorfman MD, et al. Nat Commun. 2017 Feb 22;8:14556. doi: 10.1038/ncomms14556. Nat Commun. 2017. PMID: 28223698 Free PMC article.

10

Hormones and diet, but not body weight, control hypothalamic microglial activity.

Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, Mergen C, Bour S, Thaler JP, Seeley RJ, Filosa J, Stern JE, Perez-Tilve D, Schwartz MW, Tschöp MH, Yi CX. Gao Y, et al. Glia. 2014 Jan;62(1):17-25. doi: 10.1002/glia.22580. Epub 2013 Oct 28. Glia. 2014. PMID: 24166765 Free PMC article.

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