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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. Alsamman S, et al. Sci Transl Med. 2020 Aug 19;12(557):eaay8798. doi: 10.1126/scitranslmed.aay8798. Sci Transl Med. 2020. PMID: 32817366 Free PMC article.