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DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J. Tarallo V, et al. Cell. 2012 May 11;149(4):847-59. doi: 10.1016/j.cell.2012.03.036. Epub 2012 Apr 26. Cell. 2012. PMID: 22541070 Free PMC article.
ERK1/2 activation is a therapeutic target in age-related macular degeneration.
Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton DR, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J. Dridi S, et al. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13781-6. doi: 10.1073/pnas.1206494109. Epub 2012 Aug 6. Proc Natl Acad Sci U S A. 2012. PMID: 22869729 Free PMC article.
Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.
Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J. Kleinman ME, et al. Mol Ther. 2012 Jan;20(1):101-8. doi: 10.1038/mt.2011.212. Epub 2011 Oct 11. Mol Ther. 2012. PMID: 21988875 Free PMC article.