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The mechanisms of integral membrane protein biogenesis.
Hegde RS, Keenan RJ. Hegde RS, et al. Nat Rev Mol Cell Biol. 2022 Feb;23(2):107-124. doi: 10.1038/s41580-021-00413-2. Epub 2021 Sep 23. Nat Rev Mol Cell Biol. 2022. PMID: 34556847 Review.
Translation stress and collided ribosomes are co-activators of cGAS.
Wan L, Juszkiewicz S, Blears D, Bajpe PK, Han Z, Faull P, Mitter R, Stewart A, Snijders AP, Hegde RS, Svejstrup JQ. Wan L, et al. Mol Cell. 2021 Jul 1;81(13):2808-2822.e10. doi: 10.1016/j.molcel.2021.05.018. Epub 2021 Jun 9. Mol Cell. 2021. PMID: 34111399 Free PMC article.
TTC5 mediates autoregulation of tubulin via mRNA degradation.
Lin Z, Gasic I, Chandrasekaran V, Peters N, Shao S, Mitchison TJ, Hegde RS. Lin Z, et al. Science. 2020 Jan 3;367(6473):100-104. doi: 10.1126/science.aaz4352. Epub 2019 Nov 14. Science. 2020. PMID: 31727855 Free PMC article.
ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Juszkiewicz S, Chandrasekaran V, Lin Z, Kraatz S, Ramakrishnan V, Hegde RS. Juszkiewicz S, et al. Mol Cell. 2018 Nov 1;72(3):469-481.e7. doi: 10.1016/j.molcel.2018.08.037. Epub 2018 Oct 4. Mol Cell. 2018. PMID: 30293783 Free PMC article.
The Biogenesis of Multipass Membrane Proteins.
Smalinskaitė L, Hegde RS. Smalinskaitė L, et al. Cold Spring Harb Perspect Biol. 2023 Apr 3;15(4):a041251. doi: 10.1101/cshperspect.a041251. Cold Spring Harb Perspect Biol. 2023. PMID: 36096638 Review.
A unifying model for membrane protein biogenesis.
Hegde RS, Keenan RJ. Hegde RS, et al. Nat Struct Mol Biol. 2024 Jul;31(7):1009-1017. doi: 10.1038/s41594-024-01296-5. Epub 2024 May 29. Nat Struct Mol Biol. 2024. PMID: 38811793 Free PMC article. Review.
62 results