MR/R003106/1/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2018	2
2021	4
2022	1
2023	5
2024	1

1

The molecular basis for sarcomere organization in vertebrate skeletal muscle.

Wang Z, Grange M, Wagner T, Kho AL, Gautel M, Raunser S. Wang Z, et al. Cell. 2021 Apr 15;184(8):2135-2150.e13. doi: 10.1016/j.cell.2021.02.047. Epub 2021 Mar 24. Cell. 2021. PMID: 33765442 Free PMC article.

2

Structure of the native myosin filament in the relaxed cardiac sarcomere.

Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin M, Grange M, Kho AL, Rees M, Bennett P, Gautel M, Raunser S. Tamborrini D, et al. Nature. 2023 Nov;623(7988):863-871. doi: 10.1038/s41586-023-06690-5. Epub 2023 Nov 1. Nature. 2023. PMID: 37914933 Free PMC article.

3

Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction.

Jungbluth H, Treves S, Zorzato F, Sarkozy A, Ochala J, Sewry C, Phadke R, Gautel M, Muntoni F. Jungbluth H, et al. Nat Rev Neurol. 2018 Mar;14(3):151-167. doi: 10.1038/nrneurol.2017.191. Epub 2018 Feb 2. Nat Rev Neurol. 2018. PMID: 29391587 Review.

4

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin.

Wang Z, Grange M, Pospich S, Wagner T, Kho AL, Gautel M, Raunser S. Wang Z, et al. Science. 2022 Feb 18;375(6582):eabn1934. doi: 10.1126/science.abn1934. Epub 2022 Feb 18. Science. 2022. PMID: 35175800

5

Walking with giants: The challenges of variant impact assessment in the giant sarcomeric protein titin.

Weston TGR, Rees M, Gautel M, Fraternali F. Weston TGR, et al. WIREs Mech Dis. 2024 Mar-Apr;16(2):e1638. doi: 10.1002/wsbm.1638. Epub 2023 Dec 29. WIREs Mech Dis. 2024. PMID: 38155593 Review.

6

Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers.

Koch D, Alexandrovich A, Funk F, Kho AL, Schmitt JP, Gautel M. Koch D, et al. Cell Rep. 2021 Jul 27;36(4):109448. doi: 10.1016/j.celrep.2021.109448. Cell Rep. 2021. PMID: 34320358 Free PMC article.

7

Artifact-free high-density localization microscopy analysis.

Marsh RJ, Pfisterer K, Bennett P, Hirvonen LM, Gautel M, Jones GE, Cox S. Marsh RJ, et al. Nat Methods. 2018 Sep;15(9):689-692. doi: 10.1038/s41592-018-0072-5. Epub 2018 Jul 30. Nat Methods. 2018. PMID: 30061677

8

Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation.

Rees M, Nikoopour R, Alexandrovich A, Pfuhl M, Lopes LR, Akhtar MM, Syrris P, Elliott P, Carr-White G, Gautel M. Rees M, et al. J Struct Biol. 2023 Sep;215(3):108009. doi: 10.1016/j.jsb.2023.108009. Epub 2023 Aug 5. J Struct Biol. 2023. PMID: 37549721 Free PMC article.

9

When is an obscurin variant pathogenic? The impact of Arg4344Gln and Arg4444Trp variants on protein-protein interactions and protein stability.

Fukuzawa A, Koch D, Grover S, Rees M, Gautel M. Fukuzawa A, et al. Hum Mol Genet. 2021 Jun 9;30(12):1131-1141. doi: 10.1093/hmg/ddab010. Hum Mol Genet. 2021. PMID: 33438037 Free PMC article.

10

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro.

Koch D, Kho AL, Fukuzawa A, Alexandrovich A, Vanaanen KJ, Beavil A, Pfuhl M, Rees M, Gautel M. Koch D, et al. PLoS One. 2023 Apr 20;18(4):e0284453. doi: 10.1371/journal.pone.0284453. eCollection 2023. PLoS One. 2023. PMID: 37079638 Free PMC article.

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