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Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, René O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Mäser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT. Rao SPS, et al. Science. 2023 Jun 30;380(6652):1349-1356. doi: 10.1126/science.adh0614. Epub 2023 Jun 29. Science. 2023. PMID: 37384702 Free article.
Drug resistance in Leishmania: does it really matter?
Domagalska MA, Barrett MP, Dujardin JC. Domagalska MA, et al. Trends Parasitol. 2023 Apr;39(4):251-259. doi: 10.1016/j.pt.2023.01.012. Epub 2023 Feb 17. Trends Parasitol. 2023. PMID: 36803859 Review.
Protozoan persister-like cells and drug treatment failure.
Barrett MP, Kyle DE, Sibley LD, Radke JB, Tarleton RL. Barrett MP, et al. Nat Rev Microbiol. 2019 Oct;17(10):607-620. doi: 10.1038/s41579-019-0238-x. Epub 2019 Aug 23. Nat Rev Microbiol. 2019. PMID: 31444481 Free PMC article. Review.
Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype.
Brooke DP, McGee LMC, Giordani F, Cross JM, Khalaf AI, Irving C, Gillingwater K, Shaw CD, Carter KC, Barrett MP, Suckling CJ, Scott FJ. Brooke DP, et al. RSC Med Chem. 2021 Jul 6;12(8):1391-1401. doi: 10.1039/d1md00110h. eCollection 2021 Aug 18. RSC Med Chem. 2021. PMID: 34447938 Free PMC article.
Proteomic analysis of glycosomes from Trypanosoma cruzi epimastigotes.
Acosta H, Burchmore R, Naula C, Gualdrón-López M, Quintero-Troconis E, Cáceres AJ, Michels PAM, Concepción JL, Quiñones W. Acosta H, et al. Mol Biochem Parasitol. 2019 Apr;229:62-74. doi: 10.1016/j.molbiopara.2019.02.008. Epub 2019 Mar 1. Mol Biochem Parasitol. 2019. PMID: 30831156 Free PMC article.
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.
Giordani F, Paape D, Vincent IM, Pountain AW, Fernández-Cortés F, Rico E, Zhang N, Morrison LJ, Freund Y, Witty MJ, Peter R, Edwards DY, Wilkes JM, van der Hooft JJJ, Regnault C, Read KD, Horn D, Field MC, Barrett MP. Giordani F, et al. PLoS Pathog. 2020 Nov 3;16(11):e1008932. doi: 10.1371/journal.ppat.1008932. eCollection 2020 Nov. PLoS Pathog. 2020. PMID: 33141865 Free PMC article.
Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT).
Koester DC, Marx VM, Williams S, Jiricek J, Dauphinais M, René O, Miller SL, Zhang L, Patra D, Chen YL, Cheung H, Gable J, Lakshminarayana SB, Osborne C, Galarneau JR, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Mäser P, Kaiser M, Ritchie R, Barrett MP, Diagana TT, Sarko C, Rao SPS. Koester DC, et al. J Med Chem. 2022 Sep 8;65(17):11776-11787. doi: 10.1021/acs.jmedchem.2c00791. Epub 2022 Aug 22. J Med Chem. 2022. PMID: 35993839 Free PMC article.
31 results