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The NLRP3-inflammasome as a sensor of organelle dysfunction.
Seoane PI, Lee B, Hoyle C, Yu S, Lopez-Castejon G, Lowe M, Brough D. Seoane PI, et al. J Cell Biol. 2020 Dec 7;219(12):e202006194. doi: 10.1083/jcb.202006194. J Cell Biol. 2020. PMID: 33044555 Free PMC article. Review.
DNA-sensing inflammasomes cause recurrent atherosclerotic stroke.
Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, Georgakis MK, Messerer D, Horn A, Shemer R, Jacqmarcq C, Picot A, Green JP, Schlegl C, Li X, Tomas L, Dutsch A, Liman TG, Endres M, Wernsdorf SR, Fürle C, Carofiglio O, Zhu J, Brough D; DEMDAS Study Group; Hornung V, Dichgans M, Vivien D, Schulz C, Dor Y, Tiedt S, Sager HB, Grosse GM, Liesz A. Cao J, et al. Nature. 2024 Sep;633(8029):433-441. doi: 10.1038/s41586-024-07803-4. Epub 2024 Aug 7. Nature. 2024. PMID: 39112714 Free PMC article.
Mechanisms of NLRP3 priming in inflammaging and age related diseases.
Gritsenko A, Green JP, Brough D, Lopez-Castejon G. Gritsenko A, et al. Cytokine Growth Factor Rev. 2020 Oct;55:15-25. doi: 10.1016/j.cytogfr.2020.08.003. Epub 2020 Aug 24. Cytokine Growth Factor Rev. 2020. PMID: 32883606 Free PMC article. Review.
Brazilin is a natural product inhibitor of the NLRP3 inflammasome.
McMahon E, El-Sayed S, Green J, Hoyle C, FitzPatrick L, Jones EV, Corrie E, Kelly RL, Challinor M, Freeman S, Bryce RA, Lawrence CB, Brough D, Kasher PR. McMahon E, et al. iScience. 2024 Jan 19;27(2):108968. doi: 10.1016/j.isci.2024.108968. eCollection 2024 Feb 16. iScience. 2024. PMID: 38327788 Free PMC article.
20 results