The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide

Affiliations

• ¹ Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, MC 0212, La Jolla, CA, 92093, USA.
• ² Department of Biochemistry and Biophysics, Oregon State University, 2011 Agricultural and Life Sciences, 2750 SW Campus Way, Corvallis, OR, 97331, USA.
• ³ Department of Biology, William Paterson University, 300 Pompton Road, Wayne, NJ, 07470, USA.
• ⁴ The Center for Algorithmic Biotechnology, Department of Statistical Modeling, St. Petersburg State University, Universitetskiy 28, Stary Peterhof, St. Petersburg, 198504, Russia.
• ⁵ Life Sciences Institute, Department of Medicinal Chemistry, Department of Chemistry, Department of Microbiology and Immunology, University of Michigan, 4008 Life Sciences Institute, 210 Washtenaw Avenue, Ann Arbor, MI, 48109, USA.
• ⁶ Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0212, La Jolla, CA, 92093, USA) address. wgerwick@ucsd.edu.