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The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions.
Lanfranchi M, Yandiev S, Meyer-Dilhet G, Ellouze S, Kerkhofs M, Dos Reis R, Garcia A, Blondet C, Amar A, Kneppers A, Polvèche H, Plassard D, Foretz M, Viollet B, Sakamoto K, Mounier R, Bourgeois CF, Raineteau O, Goillot E, Courchet J. Lanfranchi M, et al. Nat Commun. 2024 Mar 21;15(1):2487. doi: 10.1038/s41467-024-46146-6. Nat Commun. 2024. PMID: 38514619 Free PMC article.
PEN2: Metformin's new partner at lysosome.
Sakamoto K, Jessen N. Sakamoto K, et al. Cell Res. 2022 Jun;32(6):507-508. doi: 10.1038/s41422-022-00661-7. Cell Res. 2022. PMID: 35418220 Free PMC article. No abstract available.
Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans.
Peluso AA, Lundgaard AT, Babaei P, Mousovich-Neto F, Rocha AL, Damgaard MV, Bak EG, Gnanasekaran T, Dollerup OL, Trammell SAJ, Nielsen TS, Kern T, Abild CB, Sulek K, Ma T, Gerhart-Hines Z, Gillum MP, Arumugam M, Ørskov C, McCloskey D, Jessen N, Herrgård MJ, Mori MAS, Treebak JT. Peluso AA, et al. NPJ Aging. 2023 Apr 3;9(1):7. doi: 10.1038/s41514-023-00106-4. NPJ Aging. 2023. PMID: 37012386 Free PMC article.
GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal.
Senftleber NK, Andersen MK, Jørsboe E, Stæger FF, Nøhr AK, Garcia-Erill G, Meisner J, Santander CG, Balboa RF, Gilly A, Bjerregaard P, Larsen CVL, Grarup N, Jørgensen ME, Zeggini E, Moltke I, Hansen T, Albrechtsen A. Senftleber NK, et al. Eur J Hum Genet. 2024 Feb;32(2):215-223. doi: 10.1038/s41431-023-01485-8. Epub 2023 Oct 30. Eur J Hum Genet. 2024. PMID: 37903942 Free PMC article.