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Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.
Zhu R, Canena D, Sikora M, Klausberger M, Seferovic H, Mehdipour AR, Hain L, Laurent E, Monteil V, Wirnsberger G, Wieneke R, Tampé R, Kienzl NF, Mach L, Mirazimi A, Oh YJ, Penninger JM, Hummer G, Hinterdorfer P. Zhu R, et al. Nat Commun. 2022 Dec 24;13(1):7926. doi: 10.1038/s41467-022-35641-3. Nat Commun. 2022. PMID: 36566234 Free PMC article.
Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.
Hoffmann D, Mereiter S, Jin Oh Y, Monteil V, Elder E, Zhu R, Canena D, Hain L, Laurent E, Grünwald-Gruber C, Klausberger M, Jonsson G, Kellner MJ, Novatchkova M, Ticevic M, Chabloz A, Wirnsberger G, Hagelkruys A, Altmann F, Mach L, Stadlmann J, Oostenbrink C, Mirazimi A, Hinterdorfer P, Penninger JM. Hoffmann D, et al. EMBO J. 2021 Oct 1;40(19):e108375. doi: 10.15252/embj.2021108375. Epub 2021 Aug 23. EMBO J. 2021. PMID: 34375000 Free PMC article.
A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.
Chan JF, Oh YJ, Yuan S, Chu H, Yeung ML, Canena D, Chan CC, Poon VK, Chan CC, Zhang AJ, Cai JP, Ye ZW, Wen L, Yuen TT, Chik KK, Shuai H, Wang Y, Hou Y, Luo C, Chan WM, Qin Z, Sit KY, Au WK, Legendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK, Chan KH, Thomas DG, Klausberger M, Xu C, Moon JJ, Stadlmann J, Penninger JM, Oostenbrink C, Hinterdorfer P, Yuen KY, Markovitz DM. Chan JF, et al. Cell Rep Med. 2022 Oct 18;3(10):100774. doi: 10.1016/j.xcrm.2022.100774. Epub 2022 Sep 29. Cell Rep Med. 2022. PMID: 36195094 Free PMC article.