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Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimmers as HIV-1 vaccine candidates.
Zhang YN, Paynter J, Antanasijevic A, Allen JD, Eldad M, Lee YZ, Copps J, Newby ML, He L, Chavez D, Frost P, Goodroe A, Dutton J, Lanford R, Chen C, Wilson IA, Crispin M, Ward AB, Zhu J. Zhang YN, et al. Nat Commun. 2023 Apr 8;14(1):1985. doi: 10.1038/s41467-023-37742-z. Nat Commun. 2023. PMID: 37031217 Free PMC article.
An MPER antibody neutralizes HIV-1 using germline features shared among donors.
Zhang L, Irimia A, He L, Landais E, Rantalainen K, Leaman DP, Vollbrecht T, Stano A, Sands DI, Kim AS; IAVI Protocol G Investigators; Poignard P, Burton DR, Murrell B, Ward AB, Zhu J, Wilson IA, Zwick MB. Zhang L, et al. Nat Commun. 2019 Nov 26;10(1):5389. doi: 10.1038/s41467-019-12973-1. Nat Commun. 2019. PMID: 31772165 Free PMC article.
A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite.
Kumar S, Ju B, Shapero B, Lin X, Ren L, Zhang L, Li D, Zhou Z, Feng Y, Sou C, Mann CJ, Hao Y, Sarkar A, Hou J, Nunnally C, Hong K, Wang S, Ge X, Su B, Landais E, Sok D, Zwick MB, He L, Zhu J, Wilson IA, Shao Y. Kumar S, et al. Sci Adv. 2020 Sep 16;6(38):eabb1328. doi: 10.1126/sciadv.abb1328. Print 2020 Sep. Sci Adv. 2020. PMID: 32938661 Free PMC article.
12 results