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L858R/L718Q and L858R/L792H Mutations of EGFR Inducing Resistance Against Osimertinib by Forming Additional Hydrogen Bonds.
Imam IA, Al Adawi S, Liu X, Ellingson S, Brainson CF, Moseley HNB, Zinner R, Zhang S, Shao Q. Imam IA, et al. Proteins. 2024 Nov 4. doi: 10.1002/prot.26761. Online ahead of print. Proteins. 2024. PMID: 39494831
Acquired resistance to first-line treatments in various cancers both promotes cancer recurrence as well as limits effective treatment. This is true for epidermal growth factor receptor (EGFR) mutations, for which secondary EGFR mutations are one of the principal mec …
Acquired resistance to first-line treatments in various cancers both promotes cancer recurrence as well as limits effective tr …