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Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg.
Guthridge JM, Rakstang JK, Young KA, Hinshelwood J, Aslam M, Robertson A, Gipson MG, Sarrias MR, Moore WT, Meagher M, Karp D, Lambris JD, Perkins SJ, Holers VM. Guthridge JM, et al. Biochemistry. 2001 May 22;40(20):5931-41. doi: 10.1021/bi0101749. Biochemistry. 2001. PMID: 11352728
Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface.
Guthridge JM, Young K, Gipson MG, Sarrias MR, Szakonyi G, Chen XS, Malaspina A, Donoghue E, James JA, Lambris JD, Moir SA, Perkins SJ, Holers VM. Guthridge JM, et al. J Immunol. 2001 Nov 15;167(10):5758-66. doi: 10.4049/jimmunol.167.10.5758. J Immunol. 2001. PMID: 11698449