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Page 1
Structure-based design of bitopic ligands for the µ-opioid receptor.
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S. Faouzi A, et al. Nature. 2023 Jan;613(7945):767-774. doi: 10.1038/s41586-022-05588-y. Epub 2022 Nov 30. Nature. 2023. PMID: 36450356 Free PMC article.
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement.
Al-Hasani R, Gowrishankar R, Schmitz GP, Pedersen CE, Marcus DJ, Shirley SE, Hobbs TE, Elerding AJ, Renaud SJ, Jing M, Li Y, Alvarez VA, Lemos JC, Bruchas MR. Al-Hasani R, et al. Nat Neurosci. 2021 Oct;24(10):1414-1428. doi: 10.1038/s41593-021-00898-2. Epub 2021 Aug 12. Nat Neurosci. 2021. PMID: 34385700 Free PMC article.
Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System.
Massaly N, Copits BA, Wilson-Poe AR, Hipólito L, Markovic T, Yoon HJ, Liu S, Walicki MC, Bhatti DL, Sirohi S, Klaas A, Walker BM, Neve R, Cahill CM, Shoghi KI, Gereau RW 4th, McCall JG, Al-Hasani R, Bruchas MR, Morón JA. Massaly N, et al. Neuron. 2019 May 8;102(3):564-573.e6. doi: 10.1016/j.neuron.2019.02.029. Epub 2019 Mar 13. Neuron. 2019. PMID: 30878290 Free PMC article.
Dynorphin and its role in alcohol use disorder.
Karkhanis AN, Al-Hasani R. Karkhanis AN, et al. Brain Res. 2020 May 15;1735:146742. doi: 10.1016/j.brainres.2020.146742. Epub 2020 Feb 28. Brain Res. 2020. PMID: 32114059 Free PMC article. Review.
An open-source device for measuring food intake and operant behavior in rodent home-cages.
Matikainen-Ankney BA, Earnest T, Ali M, Casey E, Wang JG, Sutton AK, Legaria AA, Barclay KM, Murdaugh LB, Norris MR, Chang YH, Nguyen KP, Lin E, Reichenbach A, Clarke RE, Stark R, Conway SM, Carvalho F, Al-Hasani R, McCall JG, Creed MC, Cazares V, Buczynski MW, Krashes MJ, Andrews ZB, Kravitz AV. Matikainen-Ankney BA, et al. Elife. 2021 Mar 29;10:e66173. doi: 10.7554/eLife.66173. Elife. 2021. PMID: 33779547 Free PMC article.
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward.
Parker KE, Pedersen CE, Gomez AM, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Kash TJ, Dougherty JD, Stuber GD, Bruchas MR. Parker KE, et al. Cell. 2019 Jul 25;178(3):653-671.e19. doi: 10.1016/j.cell.2019.06.034. Cell. 2019. PMID: 31348890 Free PMC article.
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