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Page 1
L1 drives IFN in senescent cells and promotes age-associated inflammation.
De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. De Cecco M, et al. Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. Nature. 2019. PMID: 30728521 Free PMC article.
Ten things you should know about transposable elements.
Bourque G, Burns KH, Gehring M, Gorbunova V, Seluanov A, Hammell M, Imbeault M, Izsvák Z, Levin HL, Macfarlan TS, Mager DL, Feschotte C. Bourque G, et al. Genome Biol. 2018 Nov 19;19(1):199. doi: 10.1186/s13059-018-1577-z. Genome Biol. 2018. PMID: 30454069 Free PMC article. Review.
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.
Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V. Simon M, et al. Cell Metab. 2019 Apr 2;29(4):871-885.e5. doi: 10.1016/j.cmet.2019.02.014. Epub 2019 Mar 7. Cell Metab. 2019. PMID: 30853213 Free PMC article.
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V. Tian X, et al. Cell. 2019 Apr 18;177(3):622-638.e22. doi: 10.1016/j.cell.2019.03.043. Cell. 2019. PMID: 31002797 Free PMC article.
Proteomics of Long-Lived Mammals.
Tombline G, Gigas J, Macoretta N, Zacher M, Emmrich S, Zhao Y, Seluanov A, Gorbunova V. Tombline G, et al. Proteomics. 2020 Mar;20(5-6):e1800416. doi: 10.1002/pmic.201800416. Epub 2020 Jan 9. Proteomics. 2020. PMID: 31737995 Free PMC article. Review.
The conundrum of human immune system "senescence".
Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA. Pawelec G, et al. Mech Ageing Dev. 2020 Dec;192:111357. doi: 10.1016/j.mad.2020.111357. Epub 2020 Sep 17. Mech Ageing Dev. 2020. PMID: 32949594 Free PMC article. Review.
Non-canonical aging model systems and why we need them.
Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V. Valenzano DR, et al. EMBO J. 2017 Apr 13;36(8):959-963. doi: 10.15252/embj.201796837. Epub 2017 Mar 20. EMBO J. 2017. PMID: 28320740 Free PMC article. Review.
Dangerous Entrapment for NRF2.
Gorbunova V, Rezazadeh S, Seluanov A. Gorbunova V, et al. Cell. 2016 Jun 2;165(6):1312-1313. doi: 10.1016/j.cell.2016.05.061. Cell. 2016. PMID: 27259142 Free article.
22 results