R01 AG061350/AG/NIA NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	2
2020	6
2021	2
2022	5
2023	2
2024	2
2025	0

1

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.

Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. Hur JY, et al. Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2. Nature. 2020. PMID: 32879487 Free PMC article.

2

Friend, Foe or Both? Immune Activity in Alzheimer's Disease.

Frost GR, Jonas LA, Li YM. Frost GR, et al. Front Aging Neurosci. 2019 Dec 10;11:337. doi: 10.3389/fnagi.2019.00337. eCollection 2019. Front Aging Neurosci. 2019. PMID: 31920620 Free PMC article. Review.

3

Optical Nanosensor for Intracellular and Intracranial Detection of Amyloid-Beta.

Antman-Passig M, Wong E, Frost GR, Cupo C, Shah J, Agustinus A, Chen Z, Mancinelli C, Kamel M, Li T, Jonas LA, Li YM, Heller DA. Antman-Passig M, et al. ACS Nano. 2022 May 24;16(5):7269-7283. doi: 10.1021/acsnano.2c00054. Epub 2022 Apr 14. ACS Nano. 2022. PMID: 35420796 Free PMC article.

4

Cyclic microchip assay for measurement of hundreds of functional proteins in single neurons.

Yang L, Ball A, Liu J, Jain T, Li YM, Akhter F, Zhu D, Wang J. Yang L, et al. Nat Commun. 2022 Jun 21;13(1):3548. doi: 10.1038/s41467-022-31336-x. Nat Commun. 2022. PMID: 35729174 Free PMC article.

5

γ-Secretase fanning the fire of innate immunity.

Liu C, Nikain C, Li YM. Liu C, et al. Biochem Soc Trans. 2023 Aug 31;51(4):1597-1610. doi: 10.1042/BST20221445. Biochem Soc Trans. 2023. PMID: 37449907 Free PMC article. Review.

6

Functional insight into LOAD-associated microglial response genes.

Jonas LA, Jain T, Li YM. Jonas LA, et al. Open Biol. 2022 Jan;12(1):210280. doi: 10.1098/rsob.210280. Epub 2022 Jan 26. Open Biol. 2022. PMID: 35078351 Free PMC article. Review.

7

Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion.

Alexander C, Li T, Hattori Y, Chiu D, Frost GR, Jonas L, Liu C, Anderson CJ, Wong E, Park L, Iadecola C, Li YM. Alexander C, et al. Mol Psychiatry. 2022 Oct;27(10):4264-4273. doi: 10.1038/s41380-022-01676-7. Epub 2022 Jun 28. Mol Psychiatry. 2022. PMID: 35764706 Free PMC article.

8

Single-Cell Spatial MIST for Versatile, Scalable Detection of Protein Markers.

Meah A, Vedarethinam V, Bronstein R, Gujarati N, Jain T, Mallipattu SK, Li Y, Wang J. Meah A, et al. Biosensors (Basel). 2023 Aug 27;13(9):852. doi: 10.3390/bios13090852. Biosensors (Basel). 2023. PMID: 37754086 Free PMC article.

9

GSAP modulates γ-secretase specificity by inducing conformational change in PS1.

Wong E, Liao GP, Chang JC, Xu P, Li YM, Greengard P. Wong E, et al. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6385-6390. doi: 10.1073/pnas.1820160116. Epub 2019 Mar 8. Proc Natl Acad Sci U S A. 2019. PMID: 30850537 Free PMC article.

10

Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer's disease mouse model.

Frost GR, Longo V, Li T, Jonas LA, Judenhofer M, Cherry S, Koutcher J, Lekaye C, Zanzonico P, Li YM. Frost GR, et al. Sci Rep. 2020 Jun 25;10(1):10379. doi: 10.1038/s41598-020-67284-z. Sci Rep. 2020. PMID: 32587315 Free PMC article.

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