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Strategies for Targeting Senescent Cells in Human Disease.
Gasek NS, Kuchel GA, Kirkland JL, Xu M. Gasek NS, et al. Nat Aging. 2021 Oct;1(10):870-879. doi: 10.1038/s43587-021-00121-8. Epub 2021 Oct 7. Nat Aging. 2021. PMID: 34841261 Free PMC article. Review.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGPL, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Wang L, et al. Cell Metab. 2022 Jan 4;34(1):75-89.e8. doi: 10.1016/j.cmet.2021.11.002. Epub 2021 Nov 22. Cell Metab. 2022. PMID: 34813734 Free PMC article.
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function.
Wang B, Wang L, Gasek NS, Kuo CL, Nie J, Kim T, Yan P, Zhu J, Torrance BL, Zhou Y, Flores LC, Allen C, Andrade AM, Guo C, Cohn RL, Jellison ER, Bartley JM, Kuchel GA, Li S, Pirtskhalava T, Tchkonia T, Yadav S, Haynes L, Kirkland JL, Ikeno Y, Xu M. Wang B, et al. Cell Metab. 2024 Aug 6;36(8):1795-1805.e6. doi: 10.1016/j.cmet.2024.07.006. Cell Metab. 2024. PMID: 39111286
Role of Senescent Cells in Cutaneous Wound Healing.
Andrade AM, Sun M, Gasek NS, Hargis GR, Sharafieh R, Xu M. Andrade AM, et al. Biology (Basel). 2022 Nov 29;11(12):1731. doi: 10.3390/biology11121731. Biology (Basel). 2022. PMID: 36552241 Free PMC article. Review.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Langhi Prata LGP, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Wang L, et al. Cell Metab. 2022 Jan 4;34(1):186. doi: 10.1016/j.cmet.2021.12.014. Cell Metab. 2022. PMID: 34986334 Free PMC article. No abstract available.
Human Rotator Cuff Tears Reveal an Age-Dependent Increase in Markers of Cellular Senescence and Selective Removal of Senescent Cells With Dasatinib + Quercetin Increases Genetic Expression of COL1A1 In Vitro.
Hawthorne BC, Wellington IJ, Sabitsky JT, Murphy KV, Karsmarski OP, Thomas RO, LeVasseur MR, Mancini MR, Trudeau MT, Gulati S, McCarthy MBR, Cote MP, Xu M, Mazzocca AD. Hawthorne BC, et al. Arthroscopy. 2024 Jan;40(1):34-44. doi: 10.1016/j.arthro.2023.05.036. Epub 2023 Jun 23. Arthroscopy. 2024. PMID: 37356505 Free PMC article.