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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.
J Leukoc Biol. 2009 Oct;86(4):863-75. doi: 10.1189/jlb.0309189. Epub 2009 Aug 5.
J Leukoc Biol. 2009.
PMID: 19656901
Free PMC article.
Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.
Piao W, Song C, Chen H, Wahl LM, Fitzgerald KA, O'Neill LA, Medvedev AE.
Piao W, et al.
J Biol Chem. 2008 Feb 8;283(6):3109-3119. doi: 10.1074/jbc.M707400200. Epub 2007 Dec 10.
J Biol Chem. 2008.
PMID: 18070880
Free PMC article.
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Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity.
Rallabhandi P, Nhu QM, Toshchakov VY, Piao W, Medvedev AE, Hollenberg MD, Fasano A, Vogel SN.
Rallabhandi P, et al.
J Biol Chem. 2008 Sep 5;283(36):24314-25. doi: 10.1074/jbc.M804800200. Epub 2008 Jul 11.
J Biol Chem. 2008.
PMID: 18622013
Free PMC article.
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