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Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection.
Du L, Zhao G, Lin Y, Sui H, Chan C, Ma S, He Y, Jiang S, Wu C, Yuen KY, Jin DY, Zhou Y, Zheng BJ. Du L, et al. J Immunol. 2008 Jan 15;180(2):948-56. doi: 10.4049/jimmunol.180.2.948. J Immunol. 2008. PMID: 18178835 Free PMC article.