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Page 1
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
Lin X, Gaudino SJ, Jang KK, Bahadur T, Singh A, Banerjee A, Beaupre M, Chu T, Wong HT, Kim CK, Kempen C, Axelrad J, Huang H, Khalid S, Shah V, Eskiocak O, Parks OB, Berisha A, McAleer JP, Good M, Hoshino M, Blumberg R, Bialkowska AB, Gaffen SL, Kolls JK, Yang VW, Beyaz S, Cadwell K, Kumar P. Lin X, et al. Immunity. 2022 Feb 8;55(2):237-253.e8. doi: 10.1016/j.immuni.2021.12.016. Epub 2022 Jan 25. Immunity. 2022. PMID: 35081371 Free PMC article.
Decoy exosomes provide protection against bacterial toxins.
Keller MD, Ching KL, Liang FX, Dhabaria A, Tam K, Ueberheide BM, Unutmaz D, Torres VJ, Cadwell K. Keller MD, et al. Nature. 2020 Mar;579(7798):260-264. doi: 10.1038/s41586-020-2066-6. Epub 2020 Mar 4. Nature. 2020. PMID: 32132711 Free PMC article.
The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.
Matsuzawa-Ishimoto Y, Yao X, Koide A, Ueberheide BM, Axelrad JE, Reis BS, Parsa R, Neil JA, Devlin JC, Rudensky E, Dewan MZ, Cammer M, Blumberg RS, Ding Y, Ruggles KV, Mucida D, Koide S, Cadwell K. Matsuzawa-Ishimoto Y, et al. Nature. 2022 Oct;610(7932):547-554. doi: 10.1038/s41586-022-05259-y. Epub 2022 Oct 5. Nature. 2022. PMID: 36198790 Free PMC article.
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.
Spaan AN, Neehus AL, Laplantine E, Staels F, Ogishi M, Seeleuthner Y, Rapaport F, Lacey KA, Van Nieuwenhove E, Chrabieh M, Hum D, Migaud M, Izmiryan A, Lorenzo L, Kochetkov T, Heesterbeek DAC, Bardoel BW, DuMont AL, Dobbs K, Chardonnet S, Heissel S, Baslan T, Zhang P, Yang R, Bogunovic D, Wunderink HF, Haas PA, Molina H, Van Buggenhout G, Lyonnet S, Notarangelo LD, Seppänen MRJ, Weil R, Seminario G, Gomez-Tello H, Wouters C, Mesdaghi M, Shahrooei M, Bossuyt X, Sag E, Topaloglu R, Ozen S, Leavis HL, van Eijk MMJ, Bezrodnik L, Blancas Galicia L, Hovnanian A, Nassif A, Bader-Meunier B, Neven B, Meyts I, Schrijvers R, Puel A, Bustamante J, Aksentijevich I, Kastner DL, Torres VJ, Humblet-Baron S, Liston A, Abel L, Boisson B, Casanova JL. Spaan AN, et al. Science. 2022 Jun 17;376(6599):eabm6380. doi: 10.1126/science.abm6380. Epub 2022 Jun 17. Science. 2022. PMID: 35587511 Free PMC article.
Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization.
Jang KK, Heaney T, London M, Ding Y, Putzel G, Yeung F, Ercelen D, Chen YH, Axelrad J, Gurunathan S, Zhou C, Podkowik M, Arguelles N, Srivastava A, Shopsin B, Torres VJ, Keestra-Gounder AM, Pironti A, Griffin ME, Hang HC, Cadwell K. Jang KK, et al. Cell Host Microbe. 2023 Sep 13;31(9):1450-1468.e8. doi: 10.1016/j.chom.2023.08.002. Epub 2023 Aug 30. Cell Host Microbe. 2023. PMID: 37652008 Free PMC article.
The Intestinal Virome and Immunity.
Neil JA, Cadwell K. Neil JA, et al. J Immunol. 2018 Sep 15;201(6):1615-1624. doi: 10.4049/jimmunol.1800631. J Immunol. 2018. PMID: 30181300 Free PMC article. Review.
51 results