R01 AI134847/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	3
2020	1
2021	3
2022	2
2023	5
2024	5
2025	0

1

Understanding the contribution of metabolism to Mycobacterium tuberculosis drug tolerance.

Samuels AN, Wang ER, Harrison GA, Valenta JC, Stallings CL. Samuels AN, et al. Front Cell Infect Microbiol. 2022 Aug 22;12:958555. doi: 10.3389/fcimb.2022.958555. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36072222 Free PMC article. Review.

2

Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycobacterium tuberculosis.

Harrison GA, Wang ER, Cho K, Mreyoud Y, Sarkar S, Almqvist F, Patti GJ, Stallings CL. Harrison GA, et al. mBio. 2024 Mar 13;15(3):e0296823. doi: 10.1128/mbio.02968-23. Epub 2024 Jan 31. mBio. 2024. PMID: 38294237 Free PMC article.

3

Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection.

Zou Z, Singh P, Pinkner JS, Obernuefemann CLP, Xu W, Nye TM, Dodson KW, Almqvist F, Hultgren SJ, Caparon MG. Zou Z, et al. Sci Adv. 2024 Aug 2;10(31):eadn7979. doi: 10.1126/sciadv.adn7979. Epub 2024 Aug 2. Sci Adv. 2024. PMID: 39093975 Free PMC article.

4

Photoredox-Catalyzed Radical Coupling of C7-Chloromethyl-Substituted Thiazolino Ring-Fused 2-Pyridones with Quinoxalinones.

Hellgren V, Singh P, Kulkarni A, Bagheri N, Widengren J, Manavalan G, Almqvist F. Hellgren V, et al. J Org Chem. 2024 Aug 16;89(16):11802-11810. doi: 10.1021/acs.joc.4c01224. Epub 2024 Jul 25. J Org Chem. 2024. PMID: 39051977 Free PMC article.

5

Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics.

Nye TM, Tükenmez H, Singh P, Flores-Mireles AL, Obernuefemann CLP, Pinkner JS, Sarkar S, Bonde M, Lindgren AEG, Dodson KW, Johansson J, Almqvist F, Caparon MG, Hultgren SJ. Nye TM, et al. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2210912119. doi: 10.1073/pnas.2210912119. Epub 2022 Oct 17. Proc Natl Acad Sci U S A. 2022. PMID: 36252016 Free PMC article.

6

Mycobacterium tuberculosis Rv3160c is a TetR-like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c.

Tükenmez H, Sarkar S, Anoosheh S, Kruchanova A, Edström I, Harrison GA, Stallings CL, Almqvist F, Larsson C. Tükenmez H, et al. Sci Rep. 2021 Jan 15;11(1):1523. doi: 10.1038/s41598-021-81104-y. Sci Rep. 2021. PMID: 33452380 Free PMC article.

7

Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection.

Zou Z, Obernuefemann CLP, Singh P, Pinkner JS, Xu W, Nye TM, Dodson KW, Almqvist F, Hultgren SJ, Caparon MG. Zou Z, et al. bioRxiv [Preprint]. 2024 Jan 3:2024.01.02.573960. doi: 10.1101/2024.01.02.573960. bioRxiv. 2024. Update in: Sci Adv. 2024 Aug 2;10(31):eadn7979. doi: 10.1126/sciadv.adn7979 PMID: 38260261 Free PMC article. Updated. Preprint.

8

Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones.

Tyagi M, Adolfsson DE, Singh P, Ådén J, Jayaweera SW, Gharibyan A, Bharate JB, Kiss A, Sarkar S, Olofsson A, Almqvist F. Tyagi M, et al. J Org Chem. 2021 Dec 3;86(23):16582-16592. doi: 10.1021/acs.joc.1c01875. Epub 2021 Nov 12. J Org Chem. 2021. PMID: 34767366 Free PMC article.

9

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils.

Adolfsson DE, Tyagi M, Singh P, Deuschmann A, Ådén J, Gharibyan AL, Jayaweera SW, Lindgren AEG, Olofsson A, Almqvist F. Adolfsson DE, et al. J Org Chem. 2020 Nov 6;85(21):14174-14189. doi: 10.1021/acs.joc.0c01699. Epub 2020 Oct 25. J Org Chem. 2020. PMID: 33099999 Free PMC article.

10

Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycobacterium tuberculosis.

Harrison GA, Cho K, Wang ER, Sarkar S, Almqvist F, Patti GJ, Stallings CL. Harrison GA, et al. bioRxiv [Preprint]. 2023 Feb 7:2023.02.06.527416. doi: 10.1101/2023.02.06.527416. bioRxiv. 2023. Update in: mBio. 2024 Mar 13;15(3):e0296823. doi: 10.1128/mbio.02968-23 PMID: 36798348 Free PMC article. Updated. Preprint.

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