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A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria.
Chahine Z, Abel S, Hollin T, Barnes GL, Chung JH, Daub ME, Renard I, Choi JY, Vydyam P, Pal A, Alba-Argomaniz M, Banks CAS, Kirkwood J, Saraf A, Camino I, Castaneda P, Cuevas MC, De Mercado-Arnanz J, Fernandez-Alvaro E, Garcia-Perez A, Ibarz N, Viera-Morilla S, Prudhomme J, Joyner CJ, Bei AK, Florens L, Ben Mamoun C, Vanderwal CD, Le Roch KG. Chahine Z, et al. Science. 2024 Sep 27;385(6716):eadm7966. doi: 10.1126/science.adm7966. Epub 2024 Sep 27. Science. 2024. PMID: 39325875
High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development.
Gihaz S, Gareiss P, Choi JY, Renard I, Pal AC, Surovsteva Y, Chiu JE, Thekkiniath J, Plummer M, Hungerford W, Montgomery ML, Hosford A, Adams EM, Lightfoot JD, Fox D 3rd, Ojo KK, Staker BL, Fuller K, Ben Mamoun C. Gihaz S, et al. Structure. 2022 Nov 3;30(11):1494-1507.e6. doi: 10.1016/j.str.2022.09.001. Epub 2022 Sep 26. Structure. 2022. PMID: 36167065 Free PMC article.
A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.
Chahine Z, Abel S, Hollin T, Chung JH, Barnes GL, Daub ME, Renard I, Choi JY, Pratap V, Pal A, Alba-Argomaniz M, Banks C, Kirkwood J, Saraf A, Camino I, Castaneda P, Cuevas MC, De Mercado-Arnanz J, Fernandez-Alvaro E, Garcia-Perez A, Ibarz N, Viera-Morilla S, Prudhomme J, Joyner CJ, Bei AK, Florens L, Ben Mamoun C, Vanderwal CD, Le Roch KG. Chahine Z, et al. bioRxiv [Preprint]. 2023 Nov 22:2023.11.21.568162. doi: 10.1101/2023.11.21.568162. bioRxiv. 2023. Update in: Science. 2024 Sep 27;385(6716):eadm7966. doi: 10.1126/science.adm7966 PMID: 38045341 Free PMC article. Updated. Preprint.
24 results