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A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages.
Bedard M, van der Niet S, Bernard EM, Babunovic G, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O'Sullivan MP, O'Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB. Bedard M, et al. J Clin Invest. 2023 Mar 15;133(6):e161944. doi: 10.1172/JCI161944. J Clin Invest. 2023. PMID: 36757797 Free PMC article.
Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.
Luo Y, Huang CC, Howard NC, Wang X, Liu Q, Li X, Zhu J, Amariuta T, Asgari S, Ishigaki K, Calderon R, Raman S, Ramnarine AK, Mayfield JA, Moody DB, Lecca L, Fortune SM, Murray MB, Raychaudhuri S. Luo Y, et al. Nat Commun. 2024 Nov 29;15(1):10393. doi: 10.1038/s41467-024-54741-w. Nat Commun. 2024. PMID: 39613754 Free PMC article.
Mycobacteria that cause tuberculosis have retained ancestrally acquired genes for the biosynthesis of chemically diverse terpene nucleosides.
Mayfield JA, Raman S, Ramnarine AK, Mishra VK, Huang AD, Dudoit S, Buter J, Cheng TY, Young DC, Nair YM, Ouellet IG, Griebel BT, Ma S, Sherman DR, Mallet L, Rhee KY, Minnaard AJ, Branch Moody D. Mayfield JA, et al. PLoS Biol. 2024 Sep 30;22(9):e3002813. doi: 10.1371/journal.pbio.3002813. eCollection 2024 Sep. PLoS Biol. 2024. PMID: 39348416 Free PMC article.