R01 CA113431/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2006	1
2007	2
2008	1
2009	1
2010	2
2011	1
2012	1
2020	1
2021	1
2024	0

1

Evaluation of radioiodinated protein conjugates and their potential metabolites containing lysine-urea-glutamate (LuG), PEG and closo-decaborate(2-) as models for targeting astatine-211 to metastatic prostate cancer.

Li Y, Chyan MK, Hamlin DK, Nguyen H, Vessella R, Wilbur DS. Li Y, et al. Nucl Med Biol. 2021 Jan;92:217-227. doi: 10.1016/j.nucmedbio.2020.04.005. Epub 2020 May 3. Nucl Med Biol. 2021. PMID: 32409263 Free PMC article.

2

Design and synthesis of bis-biotin-containing reagents for applications utilizing monoclonal antibody-based pretargeting systems with streptavidin mutants.

Wilbur DS, Park SI, Chyan MK, Wan F, Hamlin DK, Shenoi J, Lin Y, Wilbur SM, Buchegger F, Pantelias A, Pagel JM, Press OW. Wilbur DS, et al. Bioconjug Chem. 2010 Jul 21;21(7):1225-38. doi: 10.1021/bc100030q. Bioconjug Chem. 2010. PMID: 20597486 Free PMC article.

3

Biotin reagents for antibody pretargeting. 7. Investigation of chemically inert biotinidase blocking functionalities for synthetic utility.

Wilbur DS, Hamlin DK, Chyan MK. Wilbur DS, et al. Bioconjug Chem. 2006 Nov-Dec;17(6):1514-22. doi: 10.1021/bc060084m. Bioconjug Chem. 2006. PMID: 17105231

4

Reagents for astatination of biomolecules. 4. Comparison of maleimido-closo-decaborate(2-) and meta-[(211)At]astatobenzoate conjugates for labeling anti-CD45 antibodies with [(211)At]astatine.

Wilbur DS, Thakar MS, Hamlin DK, Santos EB, Chyan MK, Nakamae H, Pagel JM, Press OW, Sandmaier BM. Wilbur DS, et al. Bioconjug Chem. 2009 Oct 21;20(10):1983-91. doi: 10.1021/bc9000799. Epub 2009 Sep 4. Bioconjug Chem. 2009. PMID: 19731929 Free PMC article.

5

Streptavidin in antibody pretargeting. 5. chemical modification of recombinant streptavidin for labeling with the alpha-particle-emitting radionuclides 213Bi and 211At.

Wilbur DS, Hamlin DK, Chyan MK, Brechbiel MW. Wilbur DS, et al. Bioconjug Chem. 2008 Jan;19(1):158-70. doi: 10.1021/bc7002428. Epub 2007 Dec 12. Bioconjug Chem. 2008. PMID: 18072725 Free PMC article.

6

Reagents for astatination of biomolecules. 2. Conjugation of anionic boron cage pendant groups to a protein provides a method for direct labeling that is stable to in vivo deastatination.

Wilbur DS, Chyan MK, Hamlin DK, Vessella RL, Wedge TJ, Hawthorne MF. Wilbur DS, et al. Bioconjug Chem. 2007 Jul-Aug;18(4):1226-40. doi: 10.1021/bc060345s. Epub 2007 Jun 21. Bioconjug Chem. 2007. PMID: 17583925

7

Reagents for astatination of biomolecules. 5. Evaluation of hydrazone linkers in (211)At- and (125)I-labeled closo-decaborate(2-) conjugates of Fab' as a means of decreasing kidney retention.

Wilbur DS, Chyan MK, Hamlin DK, Nguyen H, Vessella RL. Wilbur DS, et al. Bioconjug Chem. 2011 Jun 15;22(6):1089-102. doi: 10.1021/bc1005625. Epub 2011 May 5. Bioconjug Chem. 2011. PMID: 21513347 Free PMC article.

8

Reagents for astatination of biomolecules. 6. An intact antibody conjugated with a maleimido-closo-decaborate(2-) reagent via sulfhydryl groups had considerably higher kidney concentrations than the same antibody conjugated with an isothiocyanato-closo-decaborate(2-) reagent via lysine amines.

Wilbur DS, Chyan MK, Nakamae H, Chen Y, Hamlin DK, Santos EB, Kornblit BT, Sandmaier BM. Wilbur DS, et al. Bioconjug Chem. 2012 Mar 21;23(3):409-20. doi: 10.1021/bc200401b. Epub 2012 Feb 10. Bioconjug Chem. 2012. PMID: 22296587 Free PMC article.

9

Preparation and in vivo evaluation of radioiodinated closo-decaborate(2-) derivatives to identify structural components that provide low retention in tissues.

Wilbur DS, Chyan MK, Hamlin DK, Perry MA. Wilbur DS, et al. Nucl Med Biol. 2010 Feb;37(2):167-78. doi: 10.1016/j.nucmedbio.2009.10.004. Nucl Med Biol. 2010. PMID: 20152716 Free PMC article.

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