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A protein therapeutic modality founded on molecular regulation.
Wright CM, Wright RC, Eshleman JR, Ostermeier M. Wright CM, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16206-11. doi: 10.1073/pnas.1102803108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930952 Free PMC article.
Personalized chemotherapy profiling using cancer cell lines from selectable mice.
Kamiyama H, Rauenzahn S, Shim JS, Karikari CA, Feldmann G, Hua L, Kamiyama M, Schuler FW, Lin MT, Beaty RM, Karanam B, Liang H, Mullendore ME, Mo G, Hidalgo M, Jaffee E, Hruban RH, Jinnah HA, Roden RB, Jimeno A, Liu JO, Maitra A, Eshleman JR. Kamiyama H, et al. Clin Cancer Res. 2013 Mar 1;19(5):1139-46. doi: 10.1158/1078-0432.CCR-12-2127. Epub 2013 Jan 22. Clin Cancer Res. 2013. PMID: 23340293 Free PMC article.
Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.
Jones S, Li M, Parsons DW, Zhang X, Wesseling J, Kristel P, Schmidt MK, Markowitz S, Yan H, Bigner D, Hruban RH, Eshleman JR, Iacobuzio-Donahue CA, Goggins M, Maitra A, Malek SN, Powell S, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N. Jones S, et al. Hum Mutat. 2012 Jan;33(1):100-3. doi: 10.1002/humu.21633. Epub 2011 Nov 23. Hum Mutat. 2012. PMID: 22009941 Free PMC article.
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma.
Hector A, Montgomery EA, Karikari C, Canto M, Dunbar KB, Wang JS, Feldmann G, Hong SM, Haffner MC, Meeker AK, Holland SJ, Yu J, Heckrodt TJ, Zhang J, Ding P, Goff D, Singh R, Roa JC, Marimuthu A, Riggins GJ, Eshleman JR, Nelkin BD, Pandey A, Maitra A. Hector A, et al. Cancer Biol Ther. 2010 Nov 15;10(10):1009-18. doi: 10.4161/cbt.10.10.13248. Epub 2010 Nov 15. Cancer Biol Ther. 2010. PMID: 20818175 Free PMC article.
Mutant proteins as cancer-specific biomarkers.
Wang Q, Chaerkady R, Wu J, Hwang HJ, Papadopoulos N, Kopelovich L, Maitra A, Matthaei H, Eshleman JR, Hruban RH, Kinzler KW, Pandey A, Vogelstein B. Wang Q, et al. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2444-9. doi: 10.1073/pnas.1019203108. Epub 2011 Jan 19. Proc Natl Acad Sci U S A. 2011. PMID: 21248225 Free PMC article.
In vivo and in vitro propagation of intraductal papillary mucinous neoplasms.
Kamiyama H, Kamiyama M, Hong SM, Karikari CA, Lin MT, Borges MW, Griffith M, Young A, Norris-Kirby A, Lubek C, Mizuma M, Feldmann G, Shi C, Liang H, Goggins MG, Maitra A, Hruban RH, Eshleman JR. Kamiyama H, et al. Lab Invest. 2010 May;90(5):665-73. doi: 10.1038/labinvest.2010.51. Epub 2010 Mar 15. Lab Invest. 2010. PMID: 20231822 Free PMC article.
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