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The role of senescent cells in ageing.
van Deursen JM. van Deursen JM. Nature. 2014 May 22;509(7501):439-46. doi: 10.1038/nature13193. Nature. 2014. PMID: 24848057 Free PMC article. Review.
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Baker DJ, et al. Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3. Nature. 2016. PMID: 26840489 Free PMC article.
Senescence and apoptosis: dueling or complementary cell fates?
Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Childs BG, et al. EMBO Rep. 2014 Nov;15(11):1139-53. doi: 10.15252/embr.201439245. Epub 2014 Oct 13. EMBO Rep. 2014. PMID: 25312810 Free PMC article. Review.
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. Demaria M, et al. Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15. Cancer Discov. 2017. PMID: 27979832 Free PMC article.
Two-Step Senescence-Focused Cancer Therapies.
Sieben CJ, Sturmlechner I, van de Sluis B, van Deursen JM. Sieben CJ, et al. Trends Cell Biol. 2018 Sep;28(9):723-737. doi: 10.1016/j.tcb.2018.04.006. Epub 2018 May 17. Trends Cell Biol. 2018. PMID: 29776716 Free PMC article. Review.