R01 CA181746/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2016	2
2017	8
2018	5
2019	3
2020	3
2021	4
2022	1
2023	1
2024	1
2025	0

1

Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2.

Liao Y, Remsing Rix LL, Li X, Fang B, Izumi V, Welsh EA, Monastyrskyi A, Haura EB, Koomen JM, Doebele RC, Rix U. Liao Y, et al. Cell Chem Biol. 2024 Feb 15;31(2):284-297.e10. doi: 10.1016/j.chembiol.2023.09.011. Epub 2023 Oct 16. Cell Chem Biol. 2024. PMID: 37848034

2

The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors.

Palve V, Knezevic CE, Bejan DS, Luo Y, Li X, Novakova S, Welsh EA, Fang B, Kinose F, Haura EB, Monteiro AN, Koomen JM, Cohen MS, Lawrence HR, Rix U. Palve V, et al. Cell Chem Biol. 2022 Feb 17;29(2):202-214.e7. doi: 10.1016/j.chembiol.2021.07.008. Epub 2021 Jul 29. Cell Chem Biol. 2022. PMID: 34329582 Free PMC article.

3

Polypharmacology-based ceritinib repurposing using integrated functional proteomics.

Kuenzi BM, Remsing Rix LL, Stewart PA, Fang B, Kinose F, Bryant AT, Boyle TA, Koomen JM, Haura EB, Rix U. Kuenzi BM, et al. Nat Chem Biol. 2017 Dec;13(12):1222-1231. doi: 10.1038/nchembio.2489. Epub 2017 Oct 9. Nat Chem Biol. 2017. PMID: 28991240 Free PMC article.

4

An immunoproteomic approach to characterize the CAR interactome and signalosome.

Ramello MC, Benzaïd I, Kuenzi BM, Lienlaf-Moreno M, Kandell WM, Santiago DN, Pabón-Saldaña M, Darville L, Fang B, Rix U, Yoder S, Berglund A, Koomen JM, Haura EB, Abate-Daga D. Ramello MC, et al. Sci Signal. 2019 Feb 12;12(568):eaap9777. doi: 10.1126/scisignal.aap9777. Sci Signal. 2019. PMID: 30755478 Free PMC article.

5

Lowering Sample Requirements to Study Tyrosine Kinase Signaling Using Phosphoproteomics with the TMT Calibrator Approach.

Fang B, Izumi V, Rix LLR, Welsh E, Pike I, Reuther GW, Haura EB, Rix U, Koomen JM. Fang B, et al. Proteomics. 2020 Dec;20(24):e2000116. doi: 10.1002/pmic.202000116. Epub 2020 Sep 30. Proteomics. 2020. PMID: 32865326 Free PMC article.

6

TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors.

Cocco E, Lee JE, Kannan S, Schram AM, Won HH, Shifman S, Kulick A, Baldino L, Toska E, Arruabarrena-Aristorena A, Kittane S, Wu F, Cai Y, Arena S, Mussolin B, Kannan R, Vasan N, Gorelick AN, Berger MF, Novoplansky O, Jagadeeshan S, Liao Y, Rix U, Misale S, Taylor BS, Bardelli A, Hechtman JF, Hyman DM, Elkabets M, de Stanchina E, Verma CS, Ventura A, Drilon A, Scaltriti M. Cocco E, et al. Cancer Discov. 2021 Jan;11(1):126-141. doi: 10.1158/2159-8290.CD-20-0571. Epub 2020 Oct 1. Cancer Discov. 2021. PMID: 33004339 Free PMC article.

7

Turning liabilities into opportunities: Off-target based drug repurposing in cancer.

Palve V, Liao Y, Remsing Rix LL, Rix U. Palve V, et al. Semin Cancer Biol. 2021 Jan;68:209-229. doi: 10.1016/j.semcancer.2020.02.003. Epub 2020 Feb 7. Semin Cancer Biol. 2021. PMID: 32044472 Free PMC article. Review.

8

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer.

Mishall KM, Beadnell TC, Kuenzi BM, Klimczak DM, Superti-Furga G, Rix U, Schweppe RE. Mishall KM, et al. Oncotarget. 2017 Aug 24;8(61):103014-103031. doi: 10.18632/oncotarget.20488. eCollection 2017 Nov 28. Oncotarget. 2017. PMID: 29262541 Free PMC article.

9

APOSTL: An Interactive Galaxy Pipeline for Reproducible Analysis of Affinity Proteomics Data.

Kuenzi BM, Borne AL, Li J, Haura EB, Eschrich SA, Koomen JM, Rix U, Stewart PA. Kuenzi BM, et al. J Proteome Res. 2016 Dec 2;15(12):4747-4754. doi: 10.1021/acs.jproteome.6b00660. Epub 2016 Oct 21. J Proteome Res. 2016. PMID: 27680298 Free PMC article.

10

Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia.

Kuenzi BM, Remsing Rix LL, Kinose F, Kroeger JL, Lancet JE, Padron E, Rix U. Kuenzi BM, et al. Sci Rep. 2019 Jan 24;9(1):606. doi: 10.1038/s41598-018-37174-6. Sci Rep. 2019. PMID: 30679640 Free PMC article.

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