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SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma.
Hughes CJ, Fields KM, Danis EP, Hsu JY, Neelakantan D, Vincent MY, Gustafson AL, Oliphant MJ, Sreekanth V, Zaberezhnyy V, Costello JC, Jedlicka P, Ford HL. Hughes CJ, et al. Nat Commun. 2023 Jul 19;14(1):4357. doi: 10.1038/s41467-023-39945-w. Nat Commun. 2023. PMID: 37468459 Free PMC article.
The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth.
Parrish JK, McCann TS, Sechler M, Sobral LM, Ren W, Jones KL, Tan AC, Jedlicka P. Parrish JK, et al. Oncotarget. 2018 Sep 4;9(69):33110-33123. doi: 10.18632/oncotarget.26011. eCollection 2018 Sep 4. Oncotarget. 2018. PMID: 30237855 Free PMC article.